U-Factor®
Activates Longevity.
U-Factor® Solution Takes on Aging, Humanity’s Last Frontier
Make aging
a thing
of the past.
U-Factor® Solution is a complex ofthousands of bioactive components derived from human dental pulp.
Aging has long been considered inevitable.
However, we view it as a “variable that can be changed.”
U-Factor® Solution is a complex of thousands of bioactive compounds produced by dental pulp stem cells derived from human baby teeth.
Rather than a single active ingredient, it is the cells’ inherent “regenerative signals” themselves that work to revitalize the aging body.
To a place no one has yet reached.
U-Factor® Solution sets a new standard for longevity.
Stem cell-free
“supernatant”
A complex containing several thousand types of bioactive compounds
Greater cell repair capacity than exosomes alone
Why
Supernatant?
Stem cell culture supernatant refers to the liquid portion that does not contain cells and is a general term for the components of the original culture medium. It contains all physiologically active components secreted by stem cells, including exosomes, cytokines, other proteins secreted by cells, lactic acid, ammonia, and cell debris. Administering this “supernatant,” which contains these physiologically active substances, into the body promotes the regeneration of damaged tissue. “Stem cell culture supernatant” is expected to be more effective than “stem cell culture medium.”
Exosomes vs. Stem Cell Culture Supernatant
An experiment in which a cell sheet is intentionally damaged to observe how quickly the damage heals
Source: Shu Y et al. (2024), doi:10.1038/s41598-024-66213-8 (CC BY 4.0, modified)Cell repair rate
approximately 2.1 times
that of exosomes alone
In experiments conducted by our company, the undiluted supernatant solution demonstrated a cell repair rate approximately 2.1 times higher than that of exosomes alone. This suggests that the complex composition of the components provides repair capabilities that cannot be achieved with a single component.
Acts on multiple factors
contributing to aging
Aging is not a phenomenon caused by a single factor. Inflammation, cellular dysfunction, decreased energy production, and diminished regenerative capacity—these are part of a “network phenomenon” in which these factors are interconnected and accelerate one another. The diverse bioactive ingredients contained in U-Factor® Solution have the potential to simultaneously target the major mechanisms of aging through different pathways.
- A Key Driver of Aging
Targeting Chronic Inflammation
Resetting excessive inflammatory responses
through anti-inflammatory cytokines and exosomes
- Accumulating Zombie Cells
Affecting Cellular Aging
Senomorphic: Potential to Mitigate the Adverse Effects of Aging Cells
or Promote Their Removal
- Declining Energy = The Essence of Aging
Acts on Declining Mitochondrial Function
Through low-molecular-weight metabolites and signal transduction,
it promotes metabolic reprogramming
- Loss of Regenerative Capacity
Acts on Stem Cell Depletion
Through growth factors and exosomes,
it supports the activation of endogenous stem cells and niche remodeling
- Disruption in how genes are “used”
Influences epigenetic changes
Epigenetic Rejuvenation (a mechanism that controls the activation and deactivation of genes based on the environment and lifestyle)
- Aging = Breakdown of Information Transmission
Contributes to the breakdown of intercellular communication
Restructuring of Intercellular Signaling
2,500
or more varieties
- Cytokines and Growth Factors
- Contains various factors (such as VEGF, HGE, EGF, FGF-2, NGF, and BDNE) that may contribute to immune regulation, tissue repair, cell protection, and angiogenesis
- Extracellular matrix components
- Contains proteins (such as collagen, fibronectin, and decorin) that serve as a cellular scaffold and may contribute to tissue regeneration
- Exosomes
- Contains nanoparticles composed of proteins, lipids, and nucleic acids that mediate intercellular signaling
Reporting the World’s First
Findings
Director, Hinowa Medical
- Completion of the World’s First Prospective Interventional Study
- We conducted the world’s first “prospective interventional study” based on medical evidence involving systemic administration of U-Factor® solution to patients with ALS. The results were presented in March 2026 at the 25th Annual Meeting of the Japanese Society for Regenerative Medicine.
Protocol Number: jRCTs031230731
Study Details
- Evaluation of Safety Following Two Weeks of Continuous Administration
- Eight patients received weekly intravenous infusions of 120 mL of stem cell culture supernatant for a total of 12 weeks. No serious adverse effects were observed, suggesting the treatment is safe for clinical use.
- Signs of Improved Respiratory Function and Slowed Disease Progression
- The results of the efficacy assessment (ALSFRS-R, grip strength, %FVC) showed that in some cases, improvements in respiratory function (%FVC) or a halt in disease progression were observed, suggesting the potential for functional recovery.
Mass production achieved
using our proprietary
automated culture system
that can be produced in culture medium
U-Factor® Solution
We manufacture U-Factor® solution using an automated stem cell culture supernatant cultivation system developed in-house.
This automated cultivation system enables us to consistently supply large quantities of undiluted solution with exceptionally high ingredient concentrations.
The Scope and Potential of U-Factor® Solution
The potential applications of U-Factor® solution are not limited to specific diseases. Given its ability to act on multiple mechanisms associated with aging, it shows promise in a wide range of fields, from disease treatment to anti-aging.
Treatment of Diseases
- ALS (Amyotrophic Lateral Sclerosis)
- Muscular Dystrophy
- Aftereffects of a Stroke
- Alzheimer's Disease
- Atopic Dermatitis
- Dry Eye and Glaucoma
- Diabetes
- Hay Fever
Anti-Aging and Longevity
- Reducing wrinkles and sagging skin
- Skin brightening
- Thinning hair treatment
- Lower back pain and stiff shoulders
- Improved male sexual function
- Deep sleep and better sleep quality
- Hangover prevention
In addition to neurodegenerative diseases such as ALS, the treatment is expected to be effective across a wide range of disease areas, including diabetic vascular disorders. It is also anticipated to offer cosmetic benefits—such as the reduction of wrinkles and sagging—as well as anti-aging effects, and holds great potential to significantly improve quality of life.