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U-Factor Holdings: Pursuing the Potential of Stem Cell Culture Supernatant and Regenerative Medicine

LIVE HEALTHILY
AND AUTHENTICALLY,
EVEN AT 150 YEARS OLD.

LIMITLESS POTENTIAL

Our Vision

Toward an era where U-Factor® Solution puts an end to aging and intractable diseases

We believe in the potential of stem cell culture supernatant,
continuously expanding its applications based on quality and safety.

The U-Factor® solution we develop aims to
support the daily health of people worldwide.

Youthfulness to the skin. Hope to incurable diseases.
U-Factor® solution contributes to
people's “beautiful and healthy future.”

Business Model

A sustainable drug discovery business model enabling R&D independent of external funding

Typical drug discovery ventures operate at a loss during development, eventually selling their know-how and intellectual property to pharmaceutical companies.
U-Factor achieves high profitability and early profitability by investing revenue from supernatant products like cosmetics into drug discovery.
This unique business model enables stable operations independent of external funding while developing multiple pipelines using supernatant expected to be effective against diverse diseases.

Business Fields

In addition to our existing businesses focused on drug discovery using stem cell culture supernatant and cosmetics, we established U-Factor Holdings Co., Ltd. in February 2026 to oversee the entire group, including our core sales agency operations.

Overall Management
U-Factor Holdings Co., Ltd.
Cosmetics
Business
ReU Co., Ltd.
  • Product
    Planning
  • Product Sales
    (Domestic & Overseas)
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Drug Discovery Business
U-Factor Life Sciences Co., Ltd.
  • Research &
    Development
  • Business
    Development
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Sales Agency
Business
U-Dreamers Co., Ltd.
  • Sales Agency
    Development
  • Sales
    Support
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Healthcare
Business
Take Back Aging Co., Ltd.
  • Operational
    Support

Potential

Treatment of Intractable Diseases and Anti-Aging
Technology that could become the key to realizing humanity's dreams

Stem cell culture supernatant shows promise across all disease areas, including neurodegenerative diseases like ALS and diabetic vascular disorders.
It also holds potential for cosmetic effects like improving wrinkles and sagging skin, as well as anti-aging effects, offering significant potential to enhance quality of life.

Disease Treatment Field

Intractable Disease Treatment

  • ALS
  • Post-Cerebral Infarction Sequelae
  • Dry Eye/Glaucoma
  • Atopic Dermatitis
  • Muscular Dystrophy
  • Diabetes
  • Alzheimer's

Anti-Aging Field

Restore Youth

  • Wrinkles/Sagging
  • Skin Whitening
  • Lower Back Pain/Stiff Shoulders
  • Hangover Prevention
  • Thinning Hair Improvement
  • Male Function Enhancement
  • Deep Sleep

Message

Taking on aging—humanity’s last frontier.
U-Factor® Liquid helps control aging.

Read the message

Aging is humanity’s greatest unsolved challenge and the root cause of all intractable diseases, including neurodegenerative disorders such as ALS, immune disorders, and chronic diseases.

Through “U-Factor® Solution,” developed by U-Factor, we are tackling this fundamental challenge with the power of science.

Aging is not caused by a single factor but is a “network phenomenon” involving a chain reaction of multiple factors.
That is precisely why controlling it requires a multifaceted approach, rather than a single one.

U-Factor® Solution is a “multifunctional, integrated solution” for aging that combines diverse bioactive components such as exosomes, cytokines, growth factors, and low-molecular-weight metabolites. It is this very multi-component nature that holds the potential to unravel and control the intricately intertwined mechanisms of aging.

“There is no simple solution to the complexity of aging.”
It simultaneously addresses the issues occurring throughout the aging process.
That is the approach of U-Factor® Solution.

“Aging cannot be treated.” “We can only watch as intractable diseases progress.”
We are challenging and overturning these once-accepted conventions with evidence.

This is not magic. It is genuine science, built upon joint research with universities and clinical data.

Turning aging into a controllable phenomenon.
Rewriting the future of intractable diseases.

We will deliver these results to global capital markets and implement them in society.

This challenge cannot be accomplished by a single company alone. Investors, distributors, healthcare professionals, and society—together with like-minded partners, we will pool our passion, engage the world, and move forward.

Turning aging into a controllable phenomenon.
We will continue to strive toward making this a reality.

Translated with DeepL.com (free version)

U-Factor Holdings Co., Ltd.
Representative Director, Hidehiro Ijima

Corporate
Profile

Company Name
U-Factor Holdings Co., Ltd.
Representative
President and CEO: Hidehiro Ijima
Director
Director and COO: Keigo Hori
Location
6-4-6 Kojimachi, Chiyoda-ku, Tokyo 102-0083
Business Activities
Formulation of Group-wide Management Strategy and Management Control
Group Companies
U-Factor Life Sciences Co., Ltd.
U-Dreamers Co., Ltd.
ReU Co., Ltd.
Take Back Aging Co., Ltd.
LIMITLESS
POTENTIAL

Please feel free to contact us regarding joint research inquiries, media requests, business partnerships, or any other matters.

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